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HRID1883126

反应详情

EQUATION

反应方程式

HRID 1883126 的结构方程式

REACTANTS

反应物

3
结构：Cn1c(C(=O)O)cc2ccccc21
HCID27695

1-Methyl-1H-indole-2-carboxylic acid

C10H9NO2

结构：NC1CCCCCC1C(=O)O
HCID4083418

2-Aminocycloheptanecarboxylic acid

C8H15NO2

结构：Cl.N#CCN
HCID11491918

Acetonitrile, 2-amino-, hydrochloride (1:1)

C2H5ClN2

PRODUCTS

生成物

1
结构：Cn1c(C(=O)N[C@H]2CCCCC[C@H]2C(=O)NCC#N)cc2ccccc21
HCID60083633

未命名化合物

PROCEDURE

实验过程

2-[(1-Methyl-1H-indole-2-carbonyl)-amino]-cycloheptanecarboxylic was prepared from 2-Aminocycloheptanecarboxylic acid (Tyger Scientific Inc., Princeton N.J.) using the procedure of Example). 1-Methyl-1H-indole-2-carboxylic acid and aminoacetonitrile hydrochloride were coupled as described in Example 1 to yield 1-Methyl-1H-indole-2-carboxylic acid [(1S,2R)-2-(cyanomethyl-carbamoyl)-cycloheptyl]-amide (compound 98).