1H-Indole-2-carboxylic acid, 1-methyl- → HCID 60083633, compound

HRID 1883126Notes

Reaction equation

HRID 1883126 reaction equation
[NH2:1][CH:2]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[C:9]([OH:11])=O.[CH3:12][N:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[C:14]1[C:22]([OH:24])=O.Cl.[NH2:26][CH2:27][C:28]#[N:29]>>[C:27]([CH2:28][NH:29][C:9]([C@@H:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C@@H:2]1[NH:1][C:22]([C:14]1[N:13]([CH3:12])[C:21]2[C:16]([CH:15]=1)=[CH:17][CH:18]=[CH:19][CH:20]=2)=[O:24])=[O:11])#[N:26]

Participants

4

Reactant 3

HCID 276951H-Indole-2-carboxylic acid, 1-methyl-HCID 40834182-Aminocycloheptanecarboxylic acidHCID 11491918Aminoacetonitrile hydrochloride

Product 1

HCID 60083633HCID 60083633, compound

Procedure

2-[(1-Methyl-1H-indole-2-carbonyl)-amino]-cycloheptanecarboxylic was prepared from 2-Aminocycloheptanecarboxylic acid (Tyger Scientific Inc., Princeton N.J.) using the procedure of Example). 1-Methyl-1H-indole-2-carboxylic acid and aminoacetonitrile hydrochloride were coupled as described in Example 1 to yield 1-Methyl-1H-indole-2-carboxylic acid [(1S,2R)-2-(cyanomethyl-carbamoyl)-cycloheptyl]-amide (compound 98).

Sources & evidence

ORD record
ord-90c505fa1254446f8ad18170b85d65b0
Source dataset
uspto-grants-2004_07
Patent number
US06759428B2

Reaction notes

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