反应详情

A solution of [2-(cyanomethyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (7.3 g, 25.95 mmol) in formic acid (100 ml) and solution was stirred for four hours. Reaction was concentrated and then dissolved in 10% MeOH/dichloromethane solution (150 ml) Potassium carbonate was added until pH reached 9 and subsequent slurry was stirred vigorously before being filtered through Celite plug. The filtrate was concentrated in vacuo yielding 2-amino-cyclohexanecarboxylic acid cyanomethyl-amide (2.9 g, 62%).

1. customReaction
2. concentrationwas concentrated
3. dissolutiondissolved in 10% MeOH/dichloromethane solution (150 ml) Potassium carbonate
4. additionwas added until pH
5. filtrationbefore being filtered through Celite plug
6. concentrationThe filtrate was concentrated in vacuo