HCID 20740399, compound → HCID 20740295, compound

Participants

Reaction Steps

A solution of [2-(cyanomethyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (7.3 g, 25.95 mmol) in formic acid (100 ml) and solution was stirred for four hours. Reaction was concentrated and then dissolved in 10% MeOH/dichloromethane solution (150 ml) Potassium carbonate was added until pH reached 9 and subsequent slurry was stirred vigorously before being filtered through Celite plug. The filtrate was concentrated in vacuo yielding 2-amino-cyclohexanecarboxylic acid cyanomethyl-amide (2.9 g, 62%).

Provenance & Evidence