Methyl 6-bromo-1-methyl-1H-indole-2-carboxylate → 1-methyl-6-phenyl-1H-indole-2-carboxylic acid

HRID 1883134Notes

Reaction equation

HRID 1883134 reaction equation
C[O:2][C:3]([C:5]1[N:6]([CH3:15])[C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9](Br)[CH:8]=2)=[O:4].C([C@@H](NC([C@@H:26]1[CH2:31][CH2:30][CH2:29][CH2:28][C@@H:27]1NC(C1NC2C(C=1)=CC=C(C1C=CC=CC=1)C=2)=O)=O)CC(C)C)#N>>[CH3:15][N:6]1[C:7]2[C:12](=[CH:11][CH:10]=[C:9]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH:8]=2)[CH:13]=[C:5]1[C:3]([OH:2])=[O:4]

Participants

3

Reactant 2

HCID 4777911Methyl 6-bromo-1-methyl-1H-indole-2-carboxylateHCID 207402606-Phenyl-1H-indole-2-carboxylic acid [(1S,2R)-2-((S)-1-cyano-3-methyl-butylcarbamoyl)-cyclohexyl]-amide

Product 1

HCID 235102741-methyl-6-phenyl-1H-indole-2-carboxylic acid

Procedure

Similarly, 1-methyl-6-phenyl-1H-indole-2-carboxylic acid was prepared from 6-bromo-1-methyl-1H-indole-2-carboxylic acid methyl ester and was used to prepare 6-Phenyl-1H-indole-2-carboxylic acid [(1S,2R)-2-((S)-1-cyano-3-methyl-butylcarbamoyl)-cyclohexyl]-amide.

Sources & evidence

ORD record
ord-7e9132570fe1407db72e9335e4c795ae
Source dataset
uspto-grants-2004_07
Patent number
US06759428B2

Reaction notes

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