HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 1H-indole-2-carboxylate → (3-triisopropylsilanyloxy-propyl)-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 1H-indole-2-carboxylate | HCID 70992 | — |
| Reactant | (3-Bromopropoxy)tri(propan-2-yl)silane | HCID 23510097 | — |
| Product | (3-triisopropylsilanyloxy-propyl)-1H-indole-2-carboxylic acid | HCID 23510070 | — |
Reaction Steps
(3-Bromo-propoxy)-triisopropyl-silane (prepared from the corresponding alcohol, Greene, T. W. Protective Groups in Organic Chemistry; John Wiley & Sons, Inc.: New York, 1991) was reacted with 1H-indole-2-carboxylic acid methyl ester using procedures similar to Example 11 to give 1-(3-triisopropylsilanyloxy-propyl)-1H-indole-2-carboxylic acid as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06759428B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-c8318427dcd54eddb48f7149063fa024 |
| Source note | uspto-grants-2004_07 |