Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetamide | HCID 178 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Iminodiacetic acid | HCID 8897 | — |
| Reactant | Acetylglycine | HCID 10972 | — |
| Reactant | N-methyliminodiacetic acid | HCID 20441 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | N-acetyliminodiacetic acid | HCID 10130190 | 95% |
Reaction Steps
The regenerated catalyst precursor was transferred under CO:H2 pressure, into the autoclave at 95° C. containing CO:H2 (95:5) at 900 psi (6,210 kPa), acetamide (VII) (59.0 g, 1.0 mole), 95% paraformaldehyde (68.0 g, 2,16 mole), water (64.5 g, 3.60 mole) and DME (600 mL). A CO:H2 atmosphere (95:5) at 2200 psi (15,170 kPa) was immediately established. This mixture was heated to 125° C. and was maintained at this temperature for one hour. HPLC analysis of this stream gave a 95% yield of (XVI), 4% (XIV), 7.0% (XVIII), and 0.1% N-methyliminodiacetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06759549B2 |
|---|
| Source dataset | uspto-grants-2004_07 |
|---|
| ORD ID | ord-d93b8ed6803a4aa0b62dab383599ea54 |
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| Source note | uspto-grants-2004_07 |
|---|
