Acetamide → N-acetyliminodiacetic acid

HRID 1883247Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1883247
[C:1](N)(=[O:3])[CH3:2].C=O.O.[NH:8]([CH2:13][C:14]([OH:16])=[O:15])[CH2:9][C:10]([OH:12])=[O:11].C(NCC(O)=O)(=O)C.CN(CC(O)=O)CC(O)=O>COCCOC>[C:1]([N:8]([CH2:13][C:14]([OH:16])=[O:15])[CH2:9][C:10]([OH:12])=[O:11])(=[O:3])[CH3:2]

Komponenten

8

Edukt 6

HCID 178AcetamideHCID 712FormaldehydeHCID 962WaterHCID 8897Iminodiacetic acidHCID 10972AcetylglycineHCID 20441N-methyliminodiacetic acid

Produkt 1

HCID 10130190N-acetyliminodiacetic acidAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80711,2-DimethoxyethaneLösungsmittel

Reaktionsbedingungen

Temperatur
125 °C

Versuchsvorschrift

The regenerated catalyst precursor was transferred under CO:H2 pressure, into the autoclave at 95° C. containing CO:H2 (95:5) at 900 psi (6,210 kPa), acetamide (VII) (59.0 g, 1.0 mole), 95% paraformaldehyde (68.0 g, 2,16 mole), water (64.5 g, 3.60 mole) and DME (600 mL). A CO:H2 atmosphere (95:5) at 2200 psi (15,170 kPa) was immediately established. This mixture was heated to 125° C. and was maintained at this temperature for one hour. HPLC analysis of this stream gave a 95% yield of (XVI), 4% (XIV), 7.0% (XVIII), and 0.1% N-methyliminodiacetic acid.

Aufarbeitung

  1. temperaturewas maintained at this temperature for one hour

Quellen und Nachweise

ORD-Eintrag
ord-d93b8ed6803a4aa0b62dab383599ea54
Quelldatensatz
uspto-grants-2004_07
Patentnummer
US06759549B2

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