反应详情

Following General Procedure C and using (E) 2-fluoro-3-(3-methoxymethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-pent-2-enoic acid ethyl ester (Intermediate 15, 3.3 g, 8.4 mmol), CH2Cl2 (50 mL), and DIBAL-H (33.6 mL, 1.0 M in THF, 33.6 mmol) followed by flash column chromatography on silica gel (10%→20% EtOAc-hexane), the title compound was obtained as a white solid (2.4 g, 75% over 2 steps).