HCID 23510769, compound → HCID 23510753, compound

HRID 1883305Notes

Reaction equation

HRID 1883305 reaction equation
[C:1]1(=[O:25])[N:5]([CH2:6][CH2:7][CH2:8][CH:9]([C:17]([O:19]C(C)(C)C)=[O:18])[C:10]([O:12]C(C)(C)C)=[O:11])[C:4](=[O:24])[CH:3]=[CH:2]1>FC(F)(F)C(O)=O>[C:4]1(=[O:24])[N:5]([CH2:6][CH2:7][CH2:8][CH:9]([C:17]([OH:19])=[O:18])[C:10]([OH:12])=[O:11])[C:1](=[O:25])[CH:2]=[CH:3]1

Participants

3

Reactant 1

HCID 23510769HCID 23510769, compound

Product 1

HCID 23510753HCID 23510753, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The di-t-butyl ester 79 is dissolved in 20% trifluoroacetic acid and the mixture is stirred at rt for 5 h. The solvents are evaporated and the residue flushed with methylene chloride several times. The residue is triturated with ether and the resulting solid product is collected by filtration, washed with ether, and dried in vacuo.

Workup

  1. customThe solvents are evaporated
  2. customthe residue flushed with methylene chloride several times
  3. customThe residue is triturated with ether
  4. filtrationthe resulting solid product is collected by filtration
  5. washwashed with ether
  6. customdried in vacuo

Sources & evidence

ORD record
ord-3780954312b64780ba45ef7998c5b640
Source dataset
uspto-grants-2004_07
Patent number
US06759509B1

Reaction notes

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