2,4,6-Trimethylpyridine → HCID 69760009, compound

HRID 1883498Notes

Reaction equation

HRID 1883498 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[ClH:19].Cl.[NH2:21][CH2:22][CH:23]1[CH2:28][CH2:27][N:26]([C:29]([NH2:31])=[NH:30])[CH2:25][CH2:24]1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.N1C(C)=CC(C)=CC=1C>CN(C)C=O>[ClH:19].[C:1]([O:5][C:6](=[O:7])[NH:8][C@H:9]([C:10](=[O:12])[NH:21][CH2:22][CH:23]1[CH2:28][CH2:27][N:26]([C:29](=[NH:30])[NH2:31])[CH2:25][CH2:24]1)[CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)([CH3:2])([CH3:3])[CH3:4]

Participants

6

Reactant 4

HCID 79532,4,6-TrimethylpyridineHCID 27565034-(Aminomethyl)piperidine-1-carboximidamide--hydrogen chloride (1/2)HCID 7004938N-(tert-Butoxycarbonyl)-L-cyclohexylglycineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

Product 1

HCID 69760009HCID 69760009, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared using (S)-tert-butoxycarbonylamino-cyclohexyl-acetic acid (10.1 g, 39.28 mmol), 4-aminomethyl-piperidine-1-carboxamidine dihydrochloride (9.0 g, 39.28 mmol) , HATU (14.9 g, 39.28 mmol), and collidine (15.6 ml, 117.8 mmol) in dimethylformamide as described in example 223 a).

Sources & evidence

ORD record
ord-c207bce7c7c24d9b9002d061fcc84721
Source dataset
uspto-grants-2004_07
Patent number
US06759420B1

Reaction notes

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