HCID 178513294, compound → HCID 69759432, compound

HRID 1883502Notes

Reaction equation

HRID 1883502 reaction equation
O[NH:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)[C:13]([OH:15])=[O:14])=[CH:7][CH:6]=1)=[NH:4]>C(O)(=O)C.[Pd]>[C:13]([OH:15])(=[O:14])[CH3:12].[C:3]([C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH:12]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:23])([F:24])[F:25])[CH:17]=2)[C:13]([OH:15])=[O:14])=[CH:9][CH:10]=1)(=[NH:2])[NH2:4]

Participants

4

Reactant 1

HCID 178513294HCID 178513294, compound

Product 1

HCID 69759432HCID 69759432, compoundYield 130.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

3-[4-(N-Hydroxycarbamimidoyl)-phenyl]-2-(3-trifluoromethyl-phenyl)-propionic acid (680 mg, 1.93 mmol) was hydrogenated in acetic acid (50 ml) using palladium/charcoal (10%) as the catalyst. After two days, the catalyst was filtered off and the solvent evaporated in vacuo to give 500 mg of the desired product (65%). MS m/z: 337.2 (M+H)+.

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-dafdbf0dbb694e13bc2d3cb725d2cbbc
Source dataset
uspto-grants-2004_07
Patent number
US06759420B1

Reaction notes

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