HCID 53784447, compound → HCID 23509923, compound

HRID 1883506Notes

Reaction equation

HRID 1883506 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]=[C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)[C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:22])([F:23])[F:24])[CH:16]=2)[C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 53784447HCID 53784447, compound

Product 1

HCID 23509923HCID 23509923, compoundYield 99.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3-(4-Nitro-phenyl)-2-(3-trifluoromethyl-phenyl)-acrylic acid (9.9 g, 29 mmol) was hydrogenated in methanol using palladium/charcoal (10%) as the catalyst in 13 hours. The catalyst was filtered off and the filtrate was evaporated to give 8.9 g of the desired product (98% yield). MS m/z: 310.2 (M+H)+.

Workup

  1. customin 13 hours
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-b68d861231ef4cb681afed10b11e25d7
Source dataset
uspto-grants-2004_07
Patent number
US06759420B1

Reaction notes

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