2-Butyn-1-ol → HCID 57159696, compound

HRID 1883535Notes

Reaction equation

HRID 1883535 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:8]=[C:9]([CH3:23])[C:10]=1[N:11]([S:13]([C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=1)(=[O:15])=[O:14])[CH3:12])=[O:4].[CH2:30](O)[C:31]#[C:32][CH3:33]>>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:8]=[C:9]([CH3:23])[C:10]=1[N:11]([S:13]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:30][C:31]#[C:32][CH3:33])=[CH:18][CH:17]=1)(=[O:14])=[O:15])[CH3:12])=[O:4]

Participants

3

Reactant 2

HCID 129912-Butyn-1-olHCID 53962319HCID 53962319, compound

Product 1

HCID 57159696HCID 57159696, compoundYield 98%

Procedure

According to the procedure of Example 5 242 mg (0.58 mmol) of the product of Example 42 and 0.049 ml (0.65 mmol) of 2-butyn-1-ol provides 0.239 g (98%) of 4-[(4-but-2-ynyloxy-benzenesulfonyl)-methyl-amino]-5-methyl-biphenyl-3-carboxylic acid methyl ester. Electrospray Mass Spec: 464.2 (M+H)+.

Sources & evidence

ORD record
ord-46454364295d4f4796b2dc36ebcbed83
Source dataset
uspto-grants-2004_07
Patent number
US06762178B2

Reaction notes

Loading…