Methanol → HCID 505741, compound

HRID 1883546Notes

Reaction equation

HRID 1883546 reaction equation
CO.[CH3:3][NH2:4].C(O[C:8]([C:10]1[C:11]([NH:18][C:19]2[CH:20]=[C:21]3[C:25](=[CH:26][CH:27]=2)[NH:24][N:23]=[CH:22]3)=[N:12][C:13]([S:16][CH3:17])=[N:14][CH:15]=1)=[O:9])C>O>[NH:24]1[C:25]2[C:21](=[CH:20][C:19]([NH:18][C:11]3[C:10]([C:8]([NH:4][CH3:3])=[O:9])=[CH:15][N:14]=[C:13]([S:16][CH3:17])[N:12]=3)=[CH:27][CH:26]=2)[CH:22]=[N:23]1

Participants

5

Reactant 3

HCID 887MethanolHCID 6329MethylamineHCID 11209679HCID 11209679, compound

Product 1

HCID 505741HCID 505741, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
22.5 °C

Procedure

To the solution of methanol with 40% methylamine (30 ml) was added 4-(1H-5-indazolylamino)-2-methylthio-5-pyrimidine carboxylic acid ethyl ester (1.5 g) obtained by by preparation example 1, and the solution was reacted at 25-30° C. for 1 hr. The reaction mixture was cooled at 20-25° C., added H2O (90 ml) and stirred for 0.5hr. The reaction mixture was filtered, washed with 25% aqueous methanol solution (10 ml), obtained a solid product. The solid product was dried in vacuo to obtain the desired compound (1.26 g, 88%).

Workup

  1. customobtained by by preparation example 1
  2. customthe solution was reacted at 25-30° C. for 1 hr
  3. filtrationThe reaction mixture was filtered
  4. washwashed with 25% aqueous methanol solution (10 ml)
  5. customobtained a solid product
  6. customThe solid product was dried in vacuo

Sources & evidence

ORD record
ord-9d019f3d8fe54cbda7beea6ae73211c5
Source dataset
uspto-grants-2004_07
Patent number
US06762189B1

Reaction notes

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