Methanol → HCID 505743, compound

HRID 1883547Notes

Reaction equation

HRID 1883547 reaction equation
CO.C(O[C:6]([C:8]1[C:9]([NH:16][C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[NH:22][N:21]=[CH:20]3)=[N:10][C:11]([S:14][CH3:15])=[N:12][CH:13]=1)=[O:7])C.[CH2:26]([NH2:28])[CH3:27]>O>[CH2:26]([NH:28][C:6]([C:8]1[C:9]([NH:16][C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[NH:22][N:21]=[CH:20]3)=[N:10][C:11]([S:14][CH3:15])=[N:12][CH:13]=1)=[O:7])[CH3:27]

Participants

5

Reactant 3

HCID 887MethanolHCID 6341EthylamineHCID 11209679HCID 11209679, compound

Product 1

HCID 505743HCID 505743, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To the solution of methanol (20 ml) was added 4-(1H-5-indazolylamino)-2-methylthio-5-pyrimidinecarboxylic acid ethyl ester (1 g) prepared from preparation example 1, added70% aq. ethylamine (25ml) at room temperatute, and reacted at 30-35° C. for 3 hr. The reaction mixture was cooled and slowly added H2O (30 ml) and stirred for 0.5 hr. The reaction mixture was filtered, washed with 30% aqueous methanol solution (10 ml) obtained the desired compound (0.8 g, 80%)

Workup

  1. customreacted at 30-35° C. for 3 hr
  2. temperatureThe reaction mixture was cooled
  3. filtrationThe reaction mixture was filtered
  4. washwashed with 30% aqueous methanol solution (10 ml)

Sources & evidence

ORD record
ord-d6c6b699dd7a4cbf9c9de403ffff37d5
Source dataset
uspto-grants-2004_07
Patent number
US06762189B1

Reaction notes

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