Benzoyl chloride → HCID 23508176, compound

HRID 1883579Notes

Reaction equation

HRID 1883579 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][C:5]2[C:6]([CH3:14])([CH3:13])[CH2:7][N:8]([CH3:12])[CH2:9][C:10]=2[CH:11]=1.[C:15]([Cl:23])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1COCC1>[ClH:23].[CH3:12][N:8]1[CH2:7][C:6]([CH3:14])([CH3:13])[C:5]2[N:4]=[CH:3][C:2]([NH:1][C:15](=[O:22])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:11][C:10]=2[CH2:9]1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 109763193-Amino-5,6,7,8-tetrahydro-6,8,8-trimethyl[1,6]naphthyridine

Product 1

HCID 23508176HCID 23508176, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-Amino-5,6,7,8-tetrahydro-6,8,8-trimethyl [1,6]naphthyridine (96 mg, 0.50 mmol) was dissolved in dry THF (5 ml) and the solution treated with benzoyl chloride (70.3 mg; 0.50 mmol). The mixture was stirred at ambient temperature for 2 h then the precipitate collected by filtration, washed with THF, diethyl ether and dried in vacuo (132 mg; 80%).

Workup

  1. filtrationthe precipitate collected by filtration
  2. washwashed with THF, diethyl ether
  3. customdried in vacuo (132 mg; 80%)

Sources & evidence

ORD record
ord-4478b3ab6163454a99fb6988830e782d
Source dataset
uspto-grants-2004_07
Patent number
US06762192B2

Reaction notes

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