Cyclohexyl isocyanate → HCID 69892548, compound

HRID 1883614Notes

Reaction equation

HRID 1883614 reaction equation
[NH:1]=[C:2]1[NH:6][C@@H:5]([CH3:7])[C@H:4]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[S:3]1.[CH:15]1([N:21]=[C:22]=[O:23])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>C1C=CC=CC=1.C(N(CC)CC)C>[CH:15]1([NH:21][C:22]([N:1]=[C:2]2[N:6]([C:22](=[O:23])[NH:21][CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[C@@H:5]([CH3:7])[C@H:4]([C:8]3[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=3)[S:3]2)=[O:23])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

5

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 178425361HCID 178425361, compound

Product 1

HCID 69892548HCID 69892548, compoundYield 49.7%

Reagents, catalysts & solvents 2

HCID 8471TriethylamineCatalystHCID 241BenzeneSolvent

Procedure

1.0 g of trans-2-imino-4-methyl-5-(4-methylphenyl)thiazolidine was dissolved in 20 ml of benzene. To the solution were added 1.3 g of cyclohexylisocyanate and one drop of triethylamine, respectively. The mixture was stirred for an hour at room temperature and refluxed for further an hour. The reaction solution was condensed under reduced pressure. The oily product obtained was purified by column chromatography to give 1.1 g of the title compound.

Workup

  1. temperaturerefluxed for further an hour
  2. customcondensed under reduced pressure
  3. customThe oily product obtained
  4. customwas purified by column chromatography

Sources & evidence

ORD record
ord-affe8c1d956341ac9b96cfbb92894b6d
Source dataset
uspto-grants-2004_07
Patent number
US06762200B2

Reaction notes

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