反应详情

温度

100 °C

1.0 g (4.61 mmol) of 2-methyl-5-phenylbenzyl chloride (produced in the same manner as in Intermediate Production Example 10) is dissolved in 2 ml of anhydrous N,N-dimethylformamide, and to this solution is added 450 mg (6.92 mmol) of sodium cyanide, and the mixture is stirred at 100° C. Subsequently, 2 ml of toluene is added to the reaction solution and the mixture is cooled to 0° C., to this is added 213 mg (4.61 mmol) of methylhydrazine, the mixture is stirred at room temperature, then, to this is added water, and the mixture is extracted with chloroform. The organic layer is washed with saturated saline, end-dried over anhydrous magnesium sulfate, and concentrated to obtain 2-methyl-4-(2-methyl-5-phenylbenzyl) semicarbazide.

1. temperaturethe mixture is cooled to 0° C.
2. stirringthe mixture is stirred at room temperature
3. extractionthe mixture is extracted with chloroform
4. washThe organic layer is washed with saturated saline
5. dry with materialend-dried over anhydrous magnesium sulfate
6. concentrationconcentrated