Trifluoroacetic acid → HCID 69758844, compound

HRID 1883648Notes

Reaction equation

HRID 1883648 reaction equation
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([O:8]C(C)(C)C)=[O:7])=[CH:4][C:3]=1[CH2:15][NH:16][C:17](=[O:20])[CH2:18][CH3:19].[C:21]([OH:27])([C:23]([F:26])([F:25])[F:24])=[O:22]>C(Cl)Cl>[F:24][C:23]([F:26])([F:25])[C:21]([OH:27])=[O:22].[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[CH2:15][NH:16][C:17](=[O:20])[CH2:18][CH3:19]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69911586HCID 69911586, compound

Product 1

HCID 69758844HCID 69758844, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of t-butyl 4-amino-3-[(N-methylacetylamino)methyl]benzoate (2.13 g, 7.65 mmole) in CH2Cl2 (150 mL) at RT was added TFA (30 mL). After 12 hr, the reaction solution was concentrated to an oil and dried under high vacuum overnight. The resulting residue was washed with hexanes and Et2O to afford the title compound (2.56 g, 7.60 mmole) as an off-white solid. This compound was used without further purification: MS (ES) m/e 223 (M+H-TFA)+.

Workup

  1. concentrationthe reaction solution was concentrated to an oil
  2. customdried under high vacuum overnight
  3. washThe resulting residue was washed with hexanes and Et2O

Sources & evidence

ORD record
ord-6aa400d9f65c45779b865b33c03a3670
Source dataset
uspto-grants-2004_07
Patent number
US06762201B1

Reaction notes

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