Trifluoroacetic acid → HCID 69759027, compound

HRID 1883651Notes

Reaction equation

HRID 1883651 reaction equation
C([C:5]1[C:13]([CH2:14][N:15]([C:17](=[O:24])[CH:18]([OH:23])[CH2:19][CH:20]([CH3:22])[CH3:21])[CH3:16])=[C:12]([NH2:25])[CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(C)(C)C.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]>C(Cl)Cl>[F:29][C:28]([F:31])([F:30])[C:26]([OH:32])=[O:27].[NH2:25][C:12]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:13]=1[CH2:14][N:15]([C:17](=[O:24])[CH:18]([OH:23])[CH2:19][CH:20]([CH3:22])[CH3:21])[CH3:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23508332HCID 23508332, compound

Product 1

HCID 69759027HCID 69759027, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of t-butyl-4-amino-3-[(2-hydroxy-4,N-dimethylpentanoylamino)methyl]benzoic acid (3.50 g, 10.0 mmole) in CH2Cl2 (20 mL) at RT was added TFA (20 mL). After 12 hr, the reaction contents were evaporated, washed with hexanes and dried under high vacuum overnight affording the title compound as an orange oil (4.42 g, 10.8 mmol). This product was used without further purification: MS (ES) m/de 295 (M+H-TFA)+.

Workup

  1. customthe reaction contents
  2. customwere evaporated
  3. washwashed with hexanes
  4. customdried under high vacuum overnight

Sources & evidence

ORD record
ord-c3c55c2753314955b6808bfc0340b823
Source dataset
uspto-grants-2004_07
Patent number
US06762201B1

Reaction notes

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