Trifluoroacetic acid → HCID 86759494, compound

HRID 1883655Notes

Reaction equation

HRID 1883655 reaction equation
C([C:5]1[C:13]([CH2:14][NH:15][C:16](=[O:24])[CH:17]([CH3:23])[CH:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)=[C:12]([NH2:25])[CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(C)(C)C.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]>C(Cl)Cl>[F:29][C:28]([F:31])([F:30])[C:26]([OH:32])=[O:27].[NH2:25][C:12]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:13]=1[CH2:14][NH:15][C:16](=[O:24])[CH:17]([CH3:23])[CH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69759254HCID 69759254, compound

Product 1

HCID 86759494HCID 86759494, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of t-butyl-4-amino-3-[(2-cyclopentyl-N-methylacetylamino)methyl]benzoic acid (0.75 g, 2.16 mmole) in CH2Cl2 (20 mL) at RT was added TFA (20 mL). After 12 hr, the reaction contents were evaporated, washed with hexanes and dried under high vacuum overnight affording the title compound (0.63 g, 2.16 mmol) as an orange oil. This product was used without further purification: MS (ES) m/e 292 (M+H-TFA)+.

Workup

  1. customthe reaction contents
  2. customwere evaporated
  3. washwashed with hexanes
  4. customdried under high vacuum overnight

Sources & evidence

ORD record
ord-64e44553ba424b019928f725422e793d
Source dataset
uspto-grants-2004_07
Patent number
US06762201B1

Reaction notes

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