反应详情

A mixture composed of 286 mg of 4-(tert-butyldimethylsilyloxy)benzyl alcohol and 1.75 ml of thionyl chloride was heated under reflux for 1 hour. After the thionyl chloride was distilled off from the reaction mixture under reduced pressure, its azeotropic distillation with toluene was carried out three times to remove any thionyl chloride. Thus, there was obtained 4-(tert-butyldimethylsilyloxy)benzyl chloride.

1. temperaturewas heated
2. temperatureunder reflux for 1 hour
3. distillationAfter the thionyl chloride was distilled off from the reaction mixture under reduced pressure, its azeotropic distillation with toluene
4. customto remove any thionyl chloride