HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-(Tert-butyldimethylsilyloxy)benzyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (4-((Tert-butyldimethylsilyl)oxy)phenyl)methanol | HCID 10014460 | — |
| Product | 4-(Tert-butyldimethylsilyloxy)benzyl chloride | HCID 11368885 | — |
Reaction Steps
A mixture composed of 286 mg of 4-(tert-butyldimethylsilyloxy)benzyl alcohol and 1.75 ml of thionyl chloride was heated under reflux for 1 hour. After the thionyl chloride was distilled off from the reaction mixture under reduced pressure, its azeotropic distillation with toluene was carried out three times to remove any thionyl chloride. Thus, there was obtained 4-(tert-butyldimethylsilyloxy)benzyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06762205B1 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-8960b069a9994b4e80cd38548c7744c7 |
| Source note | uspto-grants-2004_07 |