HCID 23508555, compound → HCID 23508418, compound

HRID 1883686Notes

Reaction equation

HRID 1883686 reaction equation
[C:1]([C:3]1[CH:21]=[CH:20][C:6]([C:7]([N:9]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18]C)=[CH:14][CH:13]=2)[CH3:10])=[O:8])=[CH:5][CH:4]=1)#[N:2]>C1(C)C=CC=CC=1>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]([N:9]([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([OH:18])=[CH:16][CH:17]=2)[CH3:10])=[O:8])=[CH:20][CH:21]=1)#[N:2]

Participants

3

Reactant 1

HCID 23508555HCID 23508555, compound

Product 1

HCID 23508418HCID 23508418, compoundYield 78.6%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The procedure of Preparation Example 2 was repeated, except that 71 mg of 4-cyano-N-(4-methoxybenzyl)-N-methylbenzamide was used in place of 4′-methoxy-2-biphenylacetonitrile, and toluene was used in place of methylene chloride. The resulting crude product was purified by TLC (using a 4:1 mixture of chloroform and acetone as the developing solvent) to obtain 53 mg of 4-cyano-N-(4-hydroxybenzyl)-N-methylbenzamide.

Workup

  1. customThe procedure of Preparation Example 2
  2. customThe resulting crude product was purified by TLC (
  3. additiona 4:1 mixture of chloroform and acetone as the developing solvent)

Sources & evidence

ORD record
ord-1a5e33cbb1f04b848deae5e5aa8da731
Source dataset
uspto-grants-2004_07
Patent number
US06762205B1

Reaction notes

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