反应详情

温度

190 °C

451 mg of 3-methoxy-N-(2-methoxyphenyl)benzamide and 1.58 g of pyridine hydrochloride were mixed, and stirred on an oil bath at 190° C. for 2 hours. After cooling, dilute hydrochloric acid was added to the reaction mixture, and the product was extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium hydrogen carbonate and dried over anhydrous sodium sulfate. After the solvent was distilled oft the resulting crude product was recrystallized from methanol to obtain 109 mg of 3-hydroxy-N-(2-hydroxyphenyl)benzamide.

1. temperatureAfter cooling
2. extractionthe product was extracted with ethyl acetate
3. washThe extract was washed with a saturated aqueous solution of sodium hydrogen carbonate
4. dry with materialdried over anhydrous sodium sulfate
5. distillationAfter the solvent was distilled oft the resulting crude product
6. customwas recrystallized from methanol