HCID 69859806, compound → HCID 23508311, compound

HRID 1883714Notes

Reaction equation

HRID 1883714 reaction equation
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([C:14]([CH3:21])=[CH:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:9]2[C:13]=1[CH2:12][CH2:11][CH2:10]2)(=[O:3])[CH3:2]>C(O)C.[Pd]>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([CH:14]([CH3:21])[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:9]2[C:13]=1[CH2:12][CH2:11][CH2:10]2)(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 69859806HCID 69859806, compound

Product 1

HCID 23508311HCID 23508311, compoundYield 86.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of ethyl 3-[7-acetylamino-indan-4-yl]-but-2-enoate (1.9 g, Reference Example 7) in ethanol (200 mL) was hydrogenated over 10% palladium on charcoal for 16 hours. The mixture was filtered through diatomaceous earth and the filtrate was evaporated to give the title compound (1.66 g).

Workup

  1. filtrationThe mixture was filtered through diatomaceous earth
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-434ee3510dec4a728e8def25a85bbf26
Source dataset
uspto-grants-2004_07
Patent number
US06762199B2

Reaction notes

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