HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxy-2-methyl-3-oxopropanoic acid → N-[4-(3-Fluoro-benzyloxy)-phenyl]-2-methyl-malonamic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxy-2-methyl-3-oxopropanoic acid | HCID 300693 | — |
| Reactant | 4-(3-Fluoro-benzyloxy)-phenylamine | HCID 16775314 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | N-[4-(3-Fluoro-benzyloxy)-phenyl]-2-methyl-malonamic Acid Methyl Ester | HCID 69008808 | — |
Reaction Steps
The title compound is prepared in analogy to example 2, starting from 4-(3-fluoro-benzyloxy)-phenylamine (as prepared in example 1b) and 2-methyl-malonic acid monomethyl ester (Nader et al., Chem. Ber. 1986, 119, 1196). Yield after flash-chromatography with dichloromethane/methanol 98:2: 40%. Colorless solid. Mp=119° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06762320B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-e28e7cb9af8f4edb87257a17855c074a |
| Source note | uspto-grants-2004_07 |