Ammonium Hydroxide → HCID 22137939, compound

HRID 1884110Notes

Reaction equation

HRID 1884110 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)=[CH:10][C:9]=1[F:23])=[O:6].[OH-].[NH4+:26]>>[F:23][C:9]1[CH:10]=[C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)[CH:12]=[CH:13][C:8]=1[NH:7][C:5](=[O:6])[CH2:4][C:3]([NH2:26])=[O:2]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 9997061HCID 9997061, compound

Product 1

HCID 22137939HCID 22137939, compoundYield 87%

Procedure

The title compound is prepared in analogy to example 3 from N-[2-fluoro-4-(3-fluoro-benzyloxy)-phenyl]-malonamic acid methyl ester and ammonium hydroxide. Yield=87%. Slightly yellow solid. MS: m/e=321.3 (M++H).

Sources & evidence

ORD record
ord-3ea6580cd7b74921a4df65a736726241
Source dataset
uspto-grants-2004_07
Patent number
US06762320B2

Reaction notes

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