3-Fluorobenzylic alcohol → 1,4-Difluoro-2-(3-fluoro-benzyloxy)-5-nitrobenzene

HRID 1884118Notes

Reaction equation

HRID 1884118 reaction equation
[F:1][C:2]1[CH:7]=[C:6](F)[C:5]([F:9])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[F:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[CH2:17][OH:18]>>[F:9][C:5]1[CH:4]=[C:3]([N+:10]([O-:12])=[O:11])[C:2]([F:1])=[CH:7][C:6]=1[O:18][CH2:17][C:16]1[CH:19]=[CH:20][CH:21]=[C:14]([F:13])[CH:15]=1

Participants

3

Reactant 2

HCID 680083-Fluorobenzylic alcoholHCID 750121,2,4-Trifluoro-5-nitrobenzene

Product 1

HCID 219200371,4-Difluoro-2-(3-fluoro-benzyloxy)-5-nitrobenzeneYield 55%

Procedure

Prepared in analogy to example 1a) from 2,4,5-trifluoronitrobenzene and 3-fluoro-benzyl alcohol. Colorless solid. Yield=55%. MS: m/e=283.1 (M+).

Sources & evidence

ORD record
ord-826d26576fa443b5b2b5be48f43ecbd7
Source dataset
uspto-grants-2004_07
Patent number
US06762320B2

Reaction notes

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