Ammonium Hydroxide → HCID 22137954, compound

HRID 1884119Notes

Reaction equation

C[O:2][C:3](=O)[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[C:12]([F:14])[C:11]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[CH:10][C:9]=1[F:24])=[O:6].[OH-].[NH4+:27]>>[F:24][C:9]1[CH:10]=[C:11]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)[C:12]([F:14])=[CH:13][C:8]=1[NH:7][C:5](=[O:6])[CH2:4][C:3]([NH2:27])=[O:2]

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 69008376HCID 69008376, compound

Product 1

HCID 22137954HCID 22137954, compoundYield 56%

Procedure

The title compound is prepared in analogy to example 3 from N-[2,5-difluoro-4-(3-fluoro-benzyloxy)-phenyl]-malonamic acid methyl ester and and ammonium hydroxide. Yield=56%. Colorless solid. MS: m/e=339.3 (M++H).

Sources & evidence

ORD record: ord-e0c69e68823c4c12a0a3693ab9c1ac25
Source dataset: uspto-grants-2004_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06762320B2

Reaction notes

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