反应详情

温度

42.5 °C

In one of the preferred embodiments 4-bromomethyl-2′-cyanobiphenyl, L-valine methyl ester, potassium carbonate and potassium iodide are taken in acetonitrile. The reaction mixture was stirred at about 40-45° C. for about 3 to 4 hours and the solvent was removed under vacuum. Water and xylene was added to reaction mass and the organic layer was separated. A solution of oxalic acid was added to the organic layer and stirred for about an hour at ambient temperature to give N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester oxalate salt.

1. customthe solvent was removed under vacuum
2. additionWater and xylene was added to reaction mass
3. customthe organic layer was separated
4. additionA solution of oxalic acid was added to the organic layer
5. stirringstirred for about an hour at ambient temperature