Indole → 3-(1H-indol-3-yl)-1-methylpyrrolidine-2,5-dione

HRID 1884827노트

반응식

HRID 1884827 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[CH3:10][N:11]1[C:15](=[O:16])[CH:14]=[CH:13][C:12]1=[O:17]>C(O)(=O)C>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:13]2[CH2:14][C:15](=[O:16])[N:11]([CH3:10])[C:12]2=[O:17])=[CH:2]1

참가 물질

4

반응물 2

HCID 798IndoleHCID 70261N-Methylmaleimide

생성물 1

HCID 153262663-(1H-indol-3-yl)-1-methylpyrrolidine-2,5-dione

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
105 °C

실험 절차

A mixture of indole (3.14 g) and N-methylmaleimide (6.2 g, 3 equiv.) in acetic acid is heated at 105° C. for 16 hr, cooled to room temperature, held for 16 hr and filtered. The filtercake is washed with acetic acid and dried to afford the title product, 5.5 g, identified by HPLC and mass spectral analyses.

후처리

  1. temperaturecooled to room temperature
  2. filtrationfiltered
  3. washThe filtercake is washed with acetic acid
  4. customdried

출처 및 근거

ORD 기록
ord-f1f25612722c4aa4af468c4c9ad03b25
출처 데이터셋
uspto-grants-2004_07
특허 번호
US06767912B2

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