反应详情

温度

105 °C

A mixture of indole (3.14 g) and N-methylmaleimide (6.2 g, 3 equiv.) in acetic acid is heated at 105° C. for 16 hr, cooled to room temperature, held for 16 hr and filtered. The filtercake is washed with acetic acid and dried to afford the title product, 5.5 g, identified by HPLC and mass spectral analyses.

1. temperaturecooled to room temperature
2. filtrationfiltered
3. washThe filtercake is washed with acetic acid
4. customdried