HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1884827Generated: October 26, 2026
Indole → 3-(1H-indol-3-yl)-1-methylpyrrolidine-2,5-dione
https://huagongshe.com/reaction/1884827
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Indole | HCID 798 | — |
| Reactant | N-Methylmaleimide | HCID 70261 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-(1H-indol-3-yl)-1-methylpyrrolidine-2,5-dione | HCID 15326266 | — |
Reaction Steps
A mixture of indole (3.14 g) and N-methylmaleimide (6.2 g, 3 equiv.) in acetic acid is heated at 105° C. for 16 hr, cooled to room temperature, held for 16 hr and filtered. The filtercake is washed with acetic acid and dried to afford the title product, 5.5 g, identified by HPLC and mass spectral analyses.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06767912B2 |
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| Source dataset | uspto-grants-2004_07 |
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| ORD ID | ord-f1f25612722c4aa4af468c4c9ad03b25 |
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| Source note | uspto-grants-2004_07 |
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