Sodium Hydroxide → HCID 23505219, compound

HRID 1885054Notes

Reaction equation

HRID 1885054 reaction equation
[Cl:1][C:2]1[C:11]([O:12][CH2:13][C:14]([F:19])([F:18])[CH:15]([F:17])[F:16])=[C:10]([S:20]([CH2:23][CH3:24])(=[O:22])=[O:21])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+]>C1COCC1.O>[Cl:1][C:2]1[C:11]([O:12][CH2:13][C:14]([F:19])([F:18])[CH:15]([F:16])[F:17])=[C:10]([S:20]([CH2:23][CH3:24])(=[O:21])=[O:22])[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 23505221HCID 23505221, compound

Product 1

HCID 23505219HCID 23505219, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

1.600 g (4.07 mmol) of methyl 2-chloro-3-(2,2,3,3-tetrafluoropropyloxy)-4-ethylsulfonylbenzoate were dissolved in a mixture of 20 ml of THF and 20 ml of water, and with 0.218 g (5.50 mmol) of sodium hydroxide was added. The mixture was stirred at RT for 12 h and concentrated. The residue was taken up in water and admixed with 6 N HCl. The precipitate was filtered off with suction and dried. This gave 2-chloro-3-(2,2,3,3-tetrafluoropropyloxy)-4-ethylsulfonylbenzoic acid in the form of a white solid.

Workup

  1. concentrationconcentrated
  2. filtrationThe precipitate was filtered off with suction
  3. customdried

Sources & evidence

ORD record
ord-9835b42c57d54ff1a4af24cc36ed4577
Source dataset
uspto-grants-2004_07
Patent number
US06768025B2

Reaction notes

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