Sodium Hydroxide → HCID 15143357, compound

HRID 1885055Notes

Reaction equation

HRID 1885055 reaction equation
[Br:1][C:2]1[C:12]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[C:11]([Br:19])[CH:10]=[CH:9][C:3]=1[C:4]([O:6]CC)=[O:5].[OH-].[Na+]>C1COCC1.O>[Br:1][C:2]1[C:12]([O:13][CH2:14][C:15]([F:16])([F:17])[F:18])=[C:11]([Br:19])[CH:10]=[CH:9][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 15143356HCID 15143356, compound

Product 1

HCID 15143357HCID 15143357, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

1.380 g (3.40 mmol) of ethyl 2,4-dibromo-3-(2,2,2-trifluoroethoxy)benzoate were dissolved in a mixture of 15 ml of THF and 15 ml of water, and 0.150 g (3.47 mmol) of NaOH was added. The mixture was stirred at RT for 12 h and concentrated to completion. The residue was taken up in water, and 6 N HCl was added. The precipitate was filtered off with suction and dried. This gave 2-chloro-2,4-dibromo-3-(2,2,2-trifluoroethoxy)benzoic acid in the form of a white solid.

Workup

  1. additionwas added
  2. concentrationconcentrated to completion
  3. addition6 N HCl was added
  4. filtrationThe precipitate was filtered off with suction
  5. customdried

Sources & evidence

ORD record
ord-f96edc47784a471483d963ec695ae554
Source dataset
uspto-grants-2004_07
Patent number
US06768025B2

Reaction notes

Loading…