Hydrochloric Acid → HCID 14534034, compound

15.3 g of LiAlH4 was added to 330 ml of dry ether, and under stirring, a solution of 53 g of the above 5-methoxycaprylic acid in 60 ml of dry ether was dropped at below 10° C. in 2 hours. After the dropping, the mixture was raised in temperature for 2 hours of stirring at 15°-20° C. After standing for 12 hours, 5%-hydrochloric acid was added to the mixture for acidification while keeping the temperature below 15° C. The mixture was then subjected to extraction with ether. The ether extract was washed successively with water, 5%-NaOH aqueous solution and water, followed by drying with anhydrous MgSO4, distilling-off of the solvent and vacuum distillation to obtain 24.5 g of 5-methoxy-1-hexanol which provided the following IR data:

1. temperatureAfter the dropping, the mixture was raised in temperature for 2 hours
2. stirringof stirring at 15°-20° C
3. customthe temperature below 15° C
4. extractionThe mixture was then subjected to extraction with ether
5. extractionThe ether extract
6. washwas washed successively with water, 5%-NaOH aqueous solution and water
7. dry with materialby drying with anhydrous MgSO4, distilling-off of the solvent and vacuum distillation

ORD record

ord-429ebe8d360a4e1ebfc97c83e90f5638

Source dataset

uspto-grants-1992_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05143643