Hydrochloric Acid → HCID 13685436, compound

HRID 1885117Notes

Reaction equation

HRID 1885117 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH2:7]([O:12][CH:13]([CH3:19])[C:14](OCC)=[O:15])[CH2:8][CH2:9][CH2:10][CH3:11].Cl>CCOCC>[CH2:7]([O:12][CH:13]([CH3:19])[CH2:14][OH:15])[CH2:8][CH2:9][CH2:10][CH3:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14693034HCID 14693034, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 13685436HCID 13685436, compoundYield 86.8%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

7.5 g of LiAlH4 was added to 250 ml of ether, and under stirring below 10° C., 46 g of the above ester was dropped in 2 hours. After the addition, the mixture was stirred for 2 hours and left standing overnight. The mixture was acidified to pH 1 with 5%-hydrochloric acid and extracted with ether. The ether layer, after being separated, was dried with anhydrous MgSO4, followd by distilling-off of the ether to obtain 31 g of 2-pentyloxypropanol.

Workup

  1. additionAfter the addition
  2. stirringthe mixture was stirred for 2 hours
  3. waitleft
  4. extractionextracted with ether
  5. customThe ether layer, after being separated
  6. dry with materialwas dried with anhydrous MgSO4, followd by distilling-off of the ether

Sources & evidence

ORD record
ord-f4444d5cad0143838f4315cb71139630
Source dataset
uspto-grants-1992_09
Patent number
US05143643

Reaction notes

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