Hydrochloric Acid → HCID 19880149, compound

HRID 1885136Notes

Reaction equation

HRID 1885136 reaction equation
[NH2:1][CH:2]([P:4]([CH2:7][CH:8]([C:10]([OH:12])=[O:11])[CH3:9])(=[O:6])[OH:5])[CH3:3].Cl.[CH3:14]O>>[NH2:1][CH:2]([P:4]([CH2:7][CH:8]([C:10]([O:12][CH3:14])=[O:11])[CH3:9])(=[O:5])[OH:6])[CH3:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887Methanol2×HCID 14134437HCID 14134437, compound

Product 1

HCID 19880149HCID 19880149, compound

Procedure

A solution of 100 mg of 1-aminoethyl-(2-carboxy-1-propyl)phosphinic acid in methanol (5 ml) was cooled to 0° C. and saturated with HCl gas. The sealed reaction mixture was then stirred 12 hours at room temperature whereupon the methanol was removed in vacuo to provide the title compound as a hydrochloride salt which was desalted via the procedure, in Example 2 using propylene oxide to provide the title compound. (80 mg).

Workup

  1. customThe sealed reaction mixture
  2. customwas removed in vacuo

Sources & evidence

ORD record
ord-e77d427607224534b3babc0fc1f73c8a
Source dataset
uspto-grants-1992_09
Patent number
US05143908

Reaction notes

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