2-Fluoroaniline → HCID 178450490, compound

HRID 1885167Notes

Reaction equation

HRID 1885167 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9]([C:14](=[CH:20]OCC)[C:15]([O:17][CH2:18][CH3:19])=[O:16])(=[O:13])[CH2:10][CH2:11][CH3:12]>>[C:9]([C:14](=[CH:20][NH:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[F:1])[C:15]([O:17][CH2:18][CH3:19])=[O:16])(=[O:13])[CH2:10][CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 95842-FluoroanilineHCID 3359484Ethyl 2-butyryl-3-ethoxyacrylate

Product 1

HCID 178450490HCID 178450490, compoundYield 58.4%

Procedure

2-Fluoroaniline (25 g, 0.23 mol) and ethyl 2-butyryl-3-ethoxyacrylate (48 g, 0.23 mol) were heated at 150° for 2 hours, then diluted with petroleum ether and left to stand overnight. Filtration and washing gave ethyl 2-butyryl-3-(2-fluorophenylamino)acrylate (37.5 g), m.p. 60°-62°.

Workup

  1. waitleft
  2. filtrationFiltration
  3. washwashing

Sources & evidence

ORD record
ord-cadb5ddf88fa47e49262cefeac66d979
Source dataset
uspto-grants-1992_09
Patent number
US05143920

Reaction notes

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