HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 3-Butyryl-4-chloro-8-acetylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 3-butyryl-8-acetyl-4(1H)-quinolone | HCID 10377755 | — |
| Product | 3-Butyryl-4-chloro-8-acetylquinoline | HCID 10265451 | — |
Reaction Steps
A solution of 3-butyryl-8-acetyl-4(1H)-quinolone (8.4 g) in phosphoryl chloride (30 ml) was heated at reflux for 1 hour, then poured onto ice and the product extracted into ether. Drying and evaporation gave crude 3-butyryl-4-chloro-8-acetylquinoline as a dark solid, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05143920 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-820a2d6e82fa4f3eba8d0efc0e662fb3 |
| Source note | uspto-grants-1992_09 |