反应详情

A solution of 3-butyryl-8-acetyl-4(1H)-quinolone (8.4 g) in phosphoryl chloride (30 ml) was heated at reflux for 1 hour, then poured onto ice and the product extracted into ether. Drying and evaporation gave crude 3-butyryl-4-chloro-8-acetylquinoline as a dark solid, which was used without further purification.

1. temperatureat reflux for 1 hour
2. additionpoured onto ice
3. extractionthe product extracted into ether
4. customDrying
5. customevaporation