HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-m-cresol → 3-Butyryl-4-(4-hydroxy-2-methylphenylamino)-8-acetylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-m-cresol | HCID 17819 | — |
| Reactant | 3-Butyryl-4-chloro-8-acetylquinoline | HCID 10265451 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Butyryl-4-(4-hydroxy-2-methylphenylamino)-8-acetylquinoline | HCID 10090040 | 24.7% |
Reaction Steps
A solution of 3-butyryl-4-chloro-8-acetylquinoline (2.0 g) and 4-amino-3-methylphenol (1.23 g, 10 mmol) in 1,4-dioxan (25 ml) was warmed briefly to reflux, then the dioxan evaporated. Chromatography (silica, 4-6% methanol in dichloromethane) and recrystallisation from ethyl acetate gave 3-butyryl-4-(4-hydroxy-2-methylphenylamino)-8-acetylquinoline (0.65 g), m.p. 183°-185°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05143920 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-020611f96fff4f0b8ad22713ed6e76b1 |
| Source note | uspto-grants-1992_09 |