HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphenyl Ether → 3-butyryl-6-benzoyloxy-8-methoxy-4(1H)-quinolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | HCID 178450503 | HCID 178450503 | — |
| Product | 3-butyryl-6-benzoyloxy-8-methoxy-4(1H)-quinolone | HCID 10406527 | 92.6% |
Reaction Steps
Ethyl 2-butyryl-3-(4-benzoyloxy-2-methoxyphenylamino)acrylate (22 g) was added portionwise to boiling diphenyl ether and heated under reflux for 45 minutes. When cool, the mixture was chromatographed (silica gel, 2% methanol in dichloromethane) to give 3-butyryl-6-benzoyloxy-8-methoxy-4(1H)-quinolone as a light brown solid (18.1 g, 92%), m.p. 102°-4°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05143920 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-ce5d07007ca5408aac654772dd235fa0 |
| Source note | uspto-grants-1992_09 |