反应详情

Ethyl 2-butyryl-3-(4-benzoyloxy-2-methoxyphenylamino)acrylate (22 g) was added portionwise to boiling diphenyl ether and heated under reflux for 45 minutes. When cool, the mixture was chromatographed (silica gel, 2% methanol in dichloromethane) to give 3-butyryl-6-benzoyloxy-8-methoxy-4(1H)-quinolone as a light brown solid (18.1 g, 92%), m.p. 102°-4°.

1. temperatureheated
2. temperatureunder reflux for 45 minutes
3. temperatureWhen cool
4. customthe mixture was chromatographed (silica gel, 2% methanol in dichloromethane)