Hydrochloric Acid → HCID 178496788, compound

HRID 1885239Notes

Reaction equation

HRID 1885239 reaction equation
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([CH:16]=[C:17]2[S:21][C:20]([NH:22][CH2:23][O:24][CH3:25])=[N:19][C:18]2=[O:26])[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:4])[CH3:3].[ClH:27]>C(Cl)Cl>[ClH:27].[CH3:15][C:12]([C:9]1[CH:8]=[C:7]([CH:16]=[C:17]2[S:21][C:20]([NH:22][CH2:23][O:24][CH3:25])=[N:19][C:18]2=[O:26])[CH:6]=[C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])[C:10]=1[OH:11])([CH3:13])[CH3:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178496787HCID 178496787, compound

Product 1

HCID 178496788HCID 178496788, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 5-[(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-2-(methoxymethylamino)-4(5H)-thiazolone (8.3 g, 0.022 mole) in 50 mL methylene chloride is treated with ethereal hydrogen chloride to give 9.1 g (quantitative yield) of pure product, mp 177°-179° C. It is recrystallized from methylene chloride-methanol-ether to give 6.0 g (66%) of analytically pure 5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-2-(methoxymethylamino)-4(5H)-thiazolone, monohydrochloride, (Z)-, mp 177°-179° C.

Sources & evidence

ORD record
ord-9df485f139f640b3b1edbbe7851e7d92
Source dataset
uspto-grants-1992_09
Patent number
US05143928

Reaction notes

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