HCID 15661459, compound → HCID 15661460, compound

HRID 1885383Notes

Reaction equation

HRID 1885383 reaction equation
O1CCCCC1[O:7][CH2:8][C:9]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]=2[CH:12]=[C:11]([C:23]([CH3:25])=[O:24])[CH:10]=1>OS(O)(=O)=O.C([O-])(O)=O.[Na+]>[OH:7][CH2:8][C:9]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]=2[CH:12]=[C:11]([C:23]([CH3:25])=[O:24])[CH:10]=1

Participants

4

Reactant 1

HCID 15661459HCID 15661459, compound

Product 1

HCID 15661460HCID 15661460, compoundYield 91.4%

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidSolventHCID 516892Sodium BicarbonateSolvent

Procedure

1-(2-Tetrahydropyranyl)oxymethyl-3-methylcarbonyl-9-fluorenone (197 mg) was dissolved in 1% H2SO4 (5 ml) and allowed to stand at room temperature for 0.5 hour. The reaction mixture was diluted with excess NaHCO3 soln (10%). The MeOH was removed under reduced pressure and the residue was extracted with EtOAc, dried and evaporated gave the product (135 mg).

Workup

  1. customThe MeOH was removed under reduced pressure
  2. extractionthe residue was extracted with EtOAc
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-c4db40c79c9847628228c6cf0a9f5dc5
Source dataset
uspto-grants-1992_09
Patent number
US05144028

Reaction notes

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