Hydrofluoric Acid → HCID 57252782, compound

Participants

Reaction Steps

A solution of 17-ethyl-1-hydroxy-12-[2'-(3"-hydroxy-4"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone in MeCl2 is treated with diethylaminosulfur triflouride and the resultant product is treated with 48% aqueous hydrofluoric acid as in Example 63 yields 17-ethyl-1-hydroxy-12-[2'-(3"-fluoro-4"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetrmethyl-11,28,dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone.

Provenance & Evidence