Hydrofluoric Acid → HCID 57252782, compound

HRID 1885437Notes

Reaction equation

HRID 1885437 reaction equation
C([CH:3]1[CH:29]=[C:28](C)[CH2:27][CH:26](C)[CH2:25][CH:24](OC)[CH:23]2[O:34][C:19](O)([CH:20](C)[CH2:21][CH:22]2OC)[C:18](=[O:39])[C:17](=[O:40])[N:16]2[CH:11]([CH2:12][CH2:13][CH2:14][CH2:15]2)[C:10](=[O:41])[O:9][CH:8](C(C)=CC2CCC(OC)C(O)C2)[CH:7](C)[CH2:6][CH2:5][C:4]1=[O:55])C.C(N(S(F)(F)F)CC)C.F>C(Cl)Cl>[CH:19]12[O:34][CH:23]([CH2:22][CH2:21][CH2:20]1)[CH2:24][CH2:25][CH2:26][CH2:27][CH:28]=[CH:29][CH2:3][C:4](=[O:55])[CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10](=[O:41])[CH:11]1[N:16]([CH2:15][CH2:14][CH2:13][CH2:12]1)[C:17](=[O:40])[C:18]2=[O:39]

Participants

5

Reactant 3

HCID 14917Hydrofluoric AcidHCID 123472(Diethylamino)sulfur trifluorideHCID 57052806HCID 57052806, compound

Product 1

HCID 57252782HCID 57252782, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 17-ethyl-1-hydroxy-12-[2'-(3"-hydroxy-4"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone in MeCl2 is treated with diethylaminosulfur triflouride and the resultant product is treated with 48% aqueous hydrofluoric acid as in Example 63 yields 17-ethyl-1-hydroxy-12-[2'-(3"-fluoro-4"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetrmethyl-11,28,dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone.

Sources & evidence

ORD record
ord-1361ef13afc244d5ad6ed355f57aef6f
Source dataset
uspto-grants-1992_09
Patent number
US05143918

Reaction notes

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