Sodium Hydroxide → HCID 53651706, compound

HRID 1885456Notes

Reaction equation

HRID 1885456 reaction equation
[C:1]1([CH2:7][O:8][CH2:9][C:10]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[CH2:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClS([N:32]=[C:33]=[O:34])(=O)=O.S(=O)(O)[O-].[Na+].[OH-].[Na+]>C1C=CC=CC=1.CCOCC.O>[CH2:12]([C@@:10]1([CH2:9][O:8][CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[NH:32][C:33](=[O:34])[CH2:11]1)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

Participants

8

Reactant 4

HCID 14798Sodium HydroxideHCID 70918Chlorosulfonyl isocyanateHCID 19764388HCID 19764388, compoundHCID 23665763Sodium Bisulfite

Product 1

HCID 53651706HCID 53651706, compound

Reagents, catalysts & solvents 3

HCID 241BenzeneSolventHCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of 3.0 g of 2-[(phenylmethoxy)methyl]-1-octadecene in 10 ml of benzene under argon is added 1.05 ml of chlorosulfonyl isocyanate. The mixture is stirred overnight and then poured into a solution of 22 g of sodium bisulfite, 100 ml of water, 5 ml of 10% sodium hydroxide and 100 ml of ether. This mixture is stirred for 2 hours, and the organic layer separated, dried and evaporated. The residue is purified by chromatography, to give 1.1 g of the desired compound as a colorless oil.

Workup

  1. stirringThis mixture is stirred for 2 hours
  2. customthe organic layer separated
  3. customdried
  4. customevaporated
  5. customThe residue is purified by chromatography

Sources & evidence

ORD record
ord-9c36fd6557184e41809f25645f4f7dc4
Source dataset
uspto-grants-1992_09
Patent number
US05144045

Reaction notes

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