反应详情

A stirred mixture of 28 g of (S)-4-[(hexadecyloxy)methyl]-2,2-dimethyl-1,3-dioxolane in 190 ml of methyl alcohol and 21 ml of 1N hydrochloric acid is refluxed for 2 hours followed by cooling in an ice bath. The resulting solid is filtered and washed with cold acetone. The solid is crystallized from acetone to give 18.2 g of crystals which liquified at ambient temperature. The resulting oil is purified by chromatography on silica gel using 1:1 ethyl acetate:hexanes. Fractions containing product are combined and evaporated to a material which is stirred with acetone at -20° C. to give 4.1 g of crystalline solid, m.p. 65°-66° C.

1. temperatureis refluxed for 2 hours
2. temperatureby cooling in an ice bath
3. filtrationThe resulting solid is filtered
4. washwashed with cold acetone
5. customThe solid is crystallized from acetone